Materials failure impact on millions of lives. Investigations at multiple scales of observation are required in order to capture the progression of the underlying physical mechanisms: it is indeed the breakdown of the basic constituents that ultimately leads to the failure of materials, of their overall structure and intended functions. The Multiscale Mechanics and Multiphysics of Materials Lab frames in this vibrant context. Our projects and studies, often in cooperation with companies or with international institutions, cover a broad spectrum of modern and complex problems of social and industrial interest. They range from the swelling and fracturing in energy storage materials, to bio-chemo-mechanical effects in cells and living tissues, from fracture propagation in solids embrittled by different mechanisms, to data-driven high performance computations of effective properties of granular materials at different strain rates.